Professor
Brian Andrews NEJM Recommendations for Medical Students and Tutors
Week
of 29th December 2016 (#75)
University
of Notre Dame Australia (Fremantle Campus)
Occasional Editorial Comment
None
Must Read Articles
Perspective
Supporting
Family Caregivers of Older Americans
A
National Academies committee has published a report raising serious concern
about the state of family caregiving for older adults in the United States and
recommending new policies and practices to make the delivery of person- and
family-centered care a reality.
EDITORIAL
Safety
of Nonsteroidal Antiinflammatory Drugs
David
T. Felson, M.D., M.P.H.
REVIEW ARTICLE
Myasthenia
Gravis
Myasthenia
gravis is an autoimmune disease associated with several autoantibodies that
attack the neuromuscular junction. Some cases are associated with thymoma. The
hallmark of management is individualized immunosuppressive therapy.
Articles Recommended for Medical Students
Perspective
Knowing
What We Don’t Know — Improving Maintenance of Certification
How
do physicians know if they are keeping up with changing foundational knowledge?
None of us are good at knowing what we don't know. Maintenance of certification
supports our professional responsibility to ensure that our clinical knowledge
is current.
ORIGINAL ARTICLE
Cardiovascular
Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis
This
randomized trial involving patients with osteoarthritis or rheumatoid arthritis
who were at increased cardiovascular risk showed the noninferiority of
celecoxib to naproxen or ibuprofen with respect to cardiovascular safety.
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL
Case
40-2016 — A 14-Month-Old Girl with Recurrent Vomiting
A
14-month-old girl presented with a 3-month history of recurrent vomiting,
without fever, abdominal pain, or diarrhea. Frontal bossing was present and the
fontanelle was full, with mild pulsations. A diagnostic test was performed.
IMAGES IN CLINICAL MEDICINE
Infected
Urachal Cyst
A
19-month-old girl presented with abdominal pain. The initial examination was
normal, but within 24 hours the umbilicus became protuberant and erythematous.
The white-cell count was elevated. CT revealed a cystic mass extending from the
umbilicus to the dome of the bladder.
IMAGES IN CLINICAL MEDICINE
Disseminated
Cysticercosis
A
23-year-old woman presented with headache, vomiting, syncope, weight gain, and
leg pain. MRI of the head and thighs revealed diffuse hyperintense cystic
lesions, and antibodies to cysticerci were detected in the serum and CSF.
Important Articles Related to Mechanisms of Disease and
Translational Research
EDITORIAL
Breathing
Easier with Fish Oil — A New Approach to Preventing Asthma?
Other Articles which should interest medical students
CLINICAL DECISIONS
Fish
Oil Supplementation in Pregnancy
This
interactive feature offers a case vignette accompanied by essays that support
either fish oil supplementation in pregnancy to reduce the risk of asthma and
lower respiratory tract infections in offspring or no supplementation. Share
your comments and vote at NEJM.org.
ORIGINAL ARTICLE
Randomized
Trial of Bilateral versus Single Internal-Thoracic-Artery Grafts
In
this trial, over 3000 patients undergoing CABG were assigned to single or
bilateral internal-thoracic-artery grafts. At 5 years, there was no difference
in mortality or cardiovascular events. More sternal wound infections occurred
with bilateral grafts.
Novel New Therapies
ORIGINAL ARTICLE
BRIEF REPORT
Regression
of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
Combined
intracavitary and intraventricular administration of chimeric antigen receptor
T cells targeting the interleukin-13 receptor produced a decrease in symptoms
and tumor regression in a patient with refractory glioblastoma.
ORIGINAL ARTICLE
Activity
of Selumetinib in Neurofibromatosis Type 1–Related Plexiform Neurofibromas
Plexiform
neurofibroma is a complication of the NF1 mutation in
neurofibromatosis that results in overactivity of the RAS pathway. Selumetinib,
a mitogen-activated protein kinase (MAPK) kinase inhibitor, induced tumor
regressions in a majority of patients.
Other articles which may be of interest to certain students
None
