Professor Brian Andrews NEJM Recommendations
Week of the 30th July 2015 (#1)
University of Notre Dame Australia Fremantle
Community-Acquired Pneumonia Requiring
Hospitalization among U.S. Adult
This is a very important article on the current state of community
acquired pneumonia. This is the most evidenced based article on this topic and
will be the state of the art article for years to come
Highly recommended for all four years
Threading the Needle — How to Stop the HIV Outbreak in Rural Indiana
Excellent public health perspective on HIV prevention and demonstrating
how advanced Australia is in this area compared with most states in the US.
Recommended for all four years
FOCUS
ON RESEARCH
Structural Approaches to Cancer Drug
Development
Structure-Guided Blockade of CSF1R Kinase in
Tenosynovial Giant-Cell Tumor
These two articles discuss new approaches to
specific cancer therapy by identifying various ways in which specific receptors
can be inhibited. This paper describes binding of an inhibitor to conserved
region of the receptor which is not the binding site, thus maintaining the
receptor in an inactivated state. The perspective indicates that in the past
year, the FDA has approved more cancer drugs than in the past 10 years with
many more to come.
This low grade locally destructive sarcoma has been
recognised by rheumatologists as “pigmented villonodular synovitis.”
Recommended as a way to refresh receptor
biology. More for BCS but important for MED300 and MED400 to be aware of what
will be happening in the near future.
Antisense Inhibition of Apolipoprotein C-III in
Patients with Hypertriglyceridemia
This article offers the chance to review lipid biology but
focus on triglycerides metabolism. It
also offers the chance to review a mechanism for specific mRNA inhibition using
antisense technology which is now being used frequently in early studies.
Recommend for all years
Strawberry Tongue
This is a picture of the
classical tongue in Kawasaki’s disease or muco-cutaneous lymph node
syndrome. Several patients present each
year in Perth.
Recommended for all students
Chagas’ Disease
This is an excellent review article on a
disease which is rarely recognised in Australia but becoming increasingly more
common in the US and may be seen occasionally in Australia in the future both
due to increased recognition and rapid international travel. You might suspect
this in a patient from South America with an undiagnosed cardiomyopathy and/or
achalasia.
A review article to be stored in your data
base, such as in Evernote for the future.
