Thursday 21 January 2016

NEJM Week of 10th December 2015 (#20)

Professor Brian Andrews NEJM Recommendations for Medical Students and Tutors
Week of the 10th December 2015 (#20)
University of Notre Dame Australia
(Fremantle Campus)

Occasional Editorial Comments

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MUST READ SECTION

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Articles Recommended for Medical Students

IMAGES IN CLINICAL MEDICINE


Cullen’s and Grey Turner’s Signs in Acute Pancreatitis


These signs are talked about frequently but uncommonly seen by students.

Required learning: Acute pancreatitis (presentation, common causes and management – but don’t forget the rare autoimmune pancreatitis associated with the IgG4 syndromes), SIRS, MODS.  
Look for Sister Mary Joseph's nodule in previous Images in Clinical Medicine 

CLINICAL PRACTICE

Thyroid Nodules


A very important area which is a frequent OSCI topic for the head and neck examination.
This area is covered in pathology, various lectures in medicine, surgery and ENT and is one of the case studies covered in MED300 medicine rotation cases.

Recommended learning:

Examination of the head and neck (don’t forget the examination of oral cavity, pharynx, sinuses, larynx and scalp), anatomy of lymphatic drainage and approaches to “lumps in the neck.”

Examination of the thyroid, thyrotoxicosis and approach to thyroid nodules

CLINICAL IMPLICATIONS OF BASIC RESEARCH

The Immune Response — Learning to Leave Well Enough Alone


This article is written by Dr. Jim Rosenbaum who is a rheumatologist and ophthalmologist at the University of Oregon, Portland. He is a world authority on systemic and autoimmune diseases involving the eye and provides a precise overview on concepts of autoimmunity and autoinflammation which is easy to understand.

CORRESPONDENCE

Ischemic Limb Gangrene with Pulses


Recommended learning: Review the causes of ischaemic limb gangrene with and without palpable pulses. Good Figure and case with pictures

Important Articles Related to Mechanisms of Disease and Translational Research

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Other areas which should be of interest to medical students

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL

Case 38-2015 — A 21-Year-Old Man with Fatigue and Weight Loss

http://www.nejm.org/doi/full/10.1056/NEJMcpc1506821

 

An interesting case of metastatic non-seminomatous germ-cell tumour of the testis with extremely high levels of hCG causing gynaecomastia and thyrotoxicosis with discussion of the mechanisms.


Recommended learning: Review testicular tumours, types and management and swellings within the scrotum.

EDITORIAL

Scabies and Global Control of Neglected Tropical Diseases


ORIGINAL ARTICLE

Mass Drug Administration for Scabies Control in a Population with Endemic Disease

http://www.nejm.org/doi/full/10.1056/NEJMoa1500987

This is a very significant population study (from Sydney, Melbourne, Darwin and Fiji) on scabies and secondary impetigo on three Fijian islands, each with a scabies prevalence ranging from 32.1 to 49%!!  Participants on the three islands were treated respectively with permethrin to a) patients and contacts, b) mass administration of permethrin and c) mass administration of ivermectin. Prevalence of scabies fell respectively to 18.8%, 15.8% and 1.8% at 12 months with a similar proportional fall in the prevalence pf impetigo. This is a major study with significance public health implications for developing countries.
Recommended learning: Identification of scabies infection, the populations affected and the management.

Perspective

My Life as a (Fake) Patient

http://www.nejm.org/doi/full/10.1056/NEJMp1508706



An interesting perspective from a professional standardized patient and when she becomes a real patient.